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    Thenomenclature for naming tumors is complex, and the readeris referred elsewhere for a complete discussion of the topic.Basically, malignant tumors arising from epithelial tissue aretermed carcinomas, while malignant tumors of mesen-chymal origin are sarcomas.Thus, malignant tumors derivedfrom hepatocytes, which are of epithelial origin, are termedhepatocellular carcinomas. How do tumor cells then manage to stabilizemutant p53? The lessons from mouse models, instead, are consistent with the ideathat other alterations during malignant transformation contribute to mutant p53 sta-bilization

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