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Cushney andMackenzie, in the beginning of 20th century, established itsaction on the heart and its use in congestive heart failure (CHF).Cardiac glycosides are found in several plantsand in toad skin (Bufotoxin). Aloading dose is used to fill the plasma compartment, followed by the start of the CRI tomaintain this. Patient-reported convenience of once-daily versus three-times-daily dosing during long-term studiesof pramipexole in early and advanced Parkinson’s disease. ers are seen.
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